Targeting mitotic kinases for anti - cancer treatment

Cancer cells proliferate unlimitedly. Therefore, targeting the proliferative capacity of cancer is one of the smartest ways to treat cancer. In this vein, understanding the basis of mitosis is essential for the advanced treatment of cancer, let alone its importance in basic biology. Indeed, recent progress in anti-cancer strategy has come from the development of a group of inhibitors targeting mitosis. Opposed to meiosis, mitosis aims to preserve its genome during proliferation. In mitosis, genetic information of the parental cell is passed to two daughter cells through equal segregation of the replicated genome. Thus, the genetic integrity in proliferating cells is guaranteed through accurate chromosome separation in mitosis. Mitosis is an ordered process orchestrated by a series of mitotic kinases and associated proteins. Sets of checkpoint mechanisms ensure the accurate segregation of the replicated genomes. Prior to mitosis, G1 restriction point,